Directs the Department of Health and Human Services (DHHS) to establish the COVID-19 Vaccine Hesitancy Elimination Program (program) as a competitive grant program to award grants of up to $10,000 to minority businesses to conduct or host public communications, health or educational initiatives, community vaccination events, social media initiatives, or other activities subject to DHHS approval. Requires DHHS to select recipients based on criteria DHHS develops, requiring priority be given to seven specified categories of minority businesses that primarily serve historically marginalized populations. Allows grant recipients to use up to 5% of their award for administrative costs. Requires submission of grant applications as provided by DHHS, and requires DHHS to continue to accept applications until all program funds are expended. 

Requires grant recipients to report to DHHS by November 1, 2022, on the use of the grant awards, and requires DHHS to report to the specified NCGA committee and division by December 1, 2022, on the grant awards allocated. Details required content of the reports. 

Appropriates $2 million from the General Fund to DHHS for 2021-22 to establish and operate the program. Effective July 1, 2021.