House committee substitute makes the following changes to the 1st edition.

Amends proposed subdivision (3) in GS 130A-33.66, requiring the Advisory Council on Rare Diseases to review each proposed bill and resolution pertaining to rare diseases, rare disease research, or rare disease care and prepare an opinion  (previously, prepare an advisory note with an opinion) on the merits of the proposed bill or resolution and any recommended changes to the measure. Directs the Advisory Council to provide the opinion to the bill sponsor within 14 calendar days after receiving a copy of the proposed bill or resolution (previously, specified as prescribed by GS 120-30.55 and did not specify the opinion is to be provided to the bill sponsor).

Deletes Section 2, enacting GS 120-30.55 (Advisory notes from the Advisory Council on Rare Diseases on legislation pertaining to rare diseases).

Deletes Section 3, extending the terms of the current members of the Advisory Council on Rare Diseases until July 31, 2021.

Deletes Section 4, appropriating funds to the Department of Health and Human Services to be allocated to the Advisory Council on Rare Diseases to prepare advisory notes for proposed bills and resolutions.

Amends the act's long title.