Amends GS 126-16 to require all state departments, agencies, and local governments to give equal opportunity for employment and compensation without regard to race, religion, color, creed, national origin, sex, age, sexual orientation, gender identity or expression, or handicapping condition to all persons otherwise qualified (previously, did not include protections for sexual orientation, gender identity or expression). Also adds sexual orientation, gender identity, and expression to GS 126-34.02(b), which lists grounds, including discrimination, for state employees and former state employees to have cases heard by way of judicial review, after completion of the agency grievance procedure and the Office of State Human Resources review.

Enacts new GS 115C-335.10, School personnel nondiscrimination policy, to require local boards of education to adopt a policy of nondiscrimination in its personnel policies and practices in regards to race, religion, color, national origin, age sex, sexual orientation, gender identity or expression, or disability. Defines school personnel for the purposes of the section. 

Specifies that the act does not require preferential treatment or special rights be provided based on sexual orientation or gender identity or expression.