Expands the definition of opiates under GS 90-89 (listing Schedule I controlled substances) to include 45 additional chemical designations. Amends GS 90-89(1a) to change the alternative names for certain fentanyl derivatives. Amends GS 90-89 to enact new subdivision GS 90-89(1b) to include Nitazene derivatives as a Schedule I controlled substance including any of the specified derivatives, their salts, isomers, or salts of isomers unless specifically utilized as part of the manufacturing process by a commercial industry of a substance or material not intended for human ingestion or consumption, as a prescription administered under medical  supervision, or for research at a recognized institution, whenever the existence of these salts, isomers, or salts of isomers is possible within the specific chemical designation or unless specifically excepted or listed in this or another schedule, structurally derived from benzimidazole by substitution at the 1-position nitrogen with an ethylamine group, and by substitution at the 2-position carbon with a benzyl group, whether or not the compound is further modified in any of specified ways. 

Revises GS 90-89(3)(mm) to read “5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT)” (currently, 5-methoxy-N-methyl-N-propyltryptamine (5-MeO-MiPT)).

Expands scope of substituted cathinones as Schedule I substance under GS 90-89(5)j to include cycloalkyl.   

Amends GS 90-89(7) (synthetic cannabinoids) to conform to statutory list. Amends GS 90-89(7)(n), synthetic cannabinoids, to add four additional groups and GS 90-89(7)(o) to delete reference to APINCACA as a substance included in the definition. 

Amends GS 90-90(2)h1 (pertaining to Schedule II controlled substances that are opioids/opiates) to read as follows: fentanyl immediate precursor chemical 4-anilino-N-phenethylpiperdine (ANPP). (Currently, Fentanyl immediate precursor chemical, 4-anilino-N-phenethyl-4-piperidine (ANPP)). Amends GS 90-91(k)11 (Schedule III controlled substances that are anabolic steroids) to change listing to Dehydrochloromethyltestosterone (currently, Dehydrochlormethyltestosterone) and GS 90-91(k)16 to Mesterolone (currently, Mesterolene).

Effective August 1, 2025.