House committee substitute to the 2nd edition makes the following changes. Amends proposed GS 90-12.8 as follows. Adds to those practitioners excluded from the statute (1) a hospice care provider and (2) a palliative care provider. Clarifies that the practitioner must provide the education described in proposed (b) and (c) on overdose prevention and the use of an opioid antagonist if the practitioner writes a prescription for a patient for a Schedule II controlled substance and any of the already specified conditions apply. Deletes the provision that allows sanctions when a practitioner prescribes to a patient a Schedule II controlled substance and does not (1) co-prescribe an opioid antagonist prescription or (2) provide the education and use information required. Adds the requirement that a pharmacist do the following when dispensing a Schedule II controlled substance if the criteria already set out in the act are met: (1) ask the individual receiving the prescription if the individual has a prescription for an opioid antagonist and offer to fill it; (2) advise the individual that the State Health Director has issued a statewide standing order allowing the pharmacist to dispense an opioid antagonist without a specific standing order allowing the pharmacist to dispense an opioid antagonist without a prescription and offer to dispense the opioid antagonist; and (3) communicate the details of the interaction to the prescriber within 72 hours of dispensing the Schedule II controlled substance. Makes additional clarifying, technical, and conforming changes, including changing the statute's caption. Amends the act's titles.