House committee substitute to the 1st edition makes the following changes. 

Maintains the act's whereas clauses. Deletes the substantive content of the act and replaces it with the following. 

Enacts new subsection (e) to GS 90-85.15B, authorizing immunizing pharmacists to administer FDA-approved drugs and biologicals via intramuscular or subcutaneous injection to human patients 18 years or older pursuant to a specific prescription order initiated by a prescriber following an exam of the individual patient that conforms to the standards of acceptable and prevailing medical practice in the State. Requires compliance with the rules jointly adopted by the NC Board of Pharmacy and the NC Medical Board. Provides that the new subsection does not limit the ability to administer vaccinations and immunizations in accordance with existing law. Effective July 1, 2022.

Directs the NC Board of Pharmacy and the NC Medical Board to, by April 1, 2022, to: (1) implement the act's provisions; (ii) establish and maintain a list of drugs and biologicals adopted pursuant to this act, including specific protocols for each drug or biological, that pharmacists may safely administer by injection; and (iii) develop record-keeping requirements, including a requirement that the pharmacist report administration of the drugs or biologicals authorized by this act to the prescriber within 72 hours. Requires drug- and biological-specific protocols to address the essential considerations and precautions the immunizing pharmacist must take before administering the drug or biological, as specified.